5 EASY FACTS ABOUT NAD+ AND ITS IMPACT ON AGING AND AGE-RELATED DISEASES DESCRIBED

7c,d). Inhibition of glycolysis altered neither replication fork progression nor the effects of NAD+ treatment, suggesting that glycolysis is just not a limiting element for NAD+-induced effects on DNA synthesis. Phenocopying the effect of BPTES, oligomycin rescued the inhibitory effect of NAD+ treatment on fork velocity partly in HeLa and fully in